Enlarged hyperechogenic substantia nigra is related to motor performance and olfaction in the elderly
Identifieur interne : 000729 ( Main/Exploration ); précédent : 000728; suivant : 000730Enlarged hyperechogenic substantia nigra is related to motor performance and olfaction in the elderly
Auteurs : Daniela Berg [Allemagne] ; Klaus Seppi [Autriche] ; Inga Liepelt [Allemagne] ; Katherine Schweitzer [Allemagne] ; Frank Wollenweber [Allemagne] ; Björn Wolf [Allemagne] ; Ulrich Dillmann [Allemagne] ; Heike Stockner [Autriche] ; Jana Godau [Allemagne] ; Stefan Kiechl [Autriche] ; Alexandra Gaenslen [Allemagne] ; Johann Willeit [Autriche] ; Adriana Di Santo [Allemagne] ; Walter Maetzler [Allemagne] ; Thomas Gasser [Allemagne] ; Werner Poewe [Autriche] ; Stefanie Behnke [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-07-30.
English descriptors
Abstract
Enlarged substantia nigra hyperechogenicity (SN+) assessed by transcranial sonography (TCS) may be associated with Parkinson's disease (PD) risk markers such as impaired motor performance and hyposmia. The aim of this multicenter cross‐sectional study was to define the association between SN+ and these risk markers in a large population older than 50 years without the diagnosis of PD. In three centers (Tuebingen, Homburg, and Innsbruck), 1,839 individuals were examined. The echostatus of the SN was assessed by TCS, motor performance by the Unified Parkinson's Disease Rating Scale (UPDRS) motor score, and olfactory function with Sniffin' Sticks. From the 1,603 subjects included in the analysis, 16.2% were SN+, 23.0% scored above zero in the UPDRS motor section, and 28.0% were hyposmic as defined by less than 75% correctly classified Sniffin' Sticks. SN+ was associated with a UPDRS motor score above zero (OR 1.45, 95% CI 1.08–1.96) and with a lower odor identification capability (OR 1.48, 95% CI 1.12–1.96). The combination of these two features (OR 1.98, 95% CI 1.25–3.15) and UPDRS motor scores ≥3 lead to higher OR. It is concluded that SN+, impaired motor performance, and hyposmia are frequently observed in the elderly and in isolation are unspecific and of limited use to predict a subject's risk for PD. Whether the association of SN+ with both impaired motor performance and hyposmia as seen in this study predicts an increased risk for the development of PD needs to be evaluated in the follow‐up investigations. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23114
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d'Innsbruck</orgName></affiliation></author><author><name sortKey="Behnke, Stefanie" sort="Behnke, Stefanie" uniqKey="Behnke S" first="Stefanie" last="Behnke">Stefanie Behnke</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Hospital, Homburg Saar</wicri:regionArea><wicri:noRegion>Homburg Saar</wicri:noRegion><wicri:noRegion>Homburg Saar</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-07-30">2010-07-30</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1464">1464</biblScope><biblScope unit="page" to="1469">1469</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C0E03284366772921F8428DB8687CCB8ED938200</idno><idno type="DOI">10.1002/mds.23114</idno><idno type="ArticleID">MDS23114</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease/parkinsonism</term><term>cohort studies</term><term>ultrasound</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Enlarged substantia nigra hyperechogenicity (SN+) assessed by transcranial sonography (TCS) may be associated with Parkinson's disease (PD) risk markers such as impaired motor performance and hyposmia. The aim of this multicenter cross‐sectional study was to define the association between SN+ and these risk markers in a large population older than 50 years without the diagnosis of PD. In three centers (Tuebingen, Homburg, and Innsbruck), 1,839 individuals were examined. The echostatus of the SN was assessed by TCS, motor performance by the Unified Parkinson's Disease Rating Scale (UPDRS) motor score, and olfactory function with Sniffin' Sticks. From the 1,603 subjects included in the analysis, 16.2% were SN+, 23.0% scored above zero in the UPDRS motor section, and 28.0% were hyposmic as defined by less than 75% correctly classified Sniffin' Sticks. SN+ was associated with a UPDRS motor score above zero (OR 1.45, 95% CI 1.08–1.96) and with a lower odor identification capability (OR 1.48, 95% CI 1.12–1.96). The combination of these two features (OR 1.98, 95% CI 1.25–3.15) and UPDRS motor scores ≥3 lead to higher OR. It is concluded that SN+, impaired motor performance, and hyposmia are frequently observed in the elderly and in isolation are unspecific and of limited use to predict a subject's risk for PD. Whether the association of SN+ with both impaired motor performance and hyposmia as seen in this study predicts an increased risk for the development of PD needs to be evaluated in the follow‐up investigations. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li></country><region><li>Tyrol (Land)</li></region><settlement><li>Innsbruck</li></settlement><orgName><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name></noRegion><name sortKey="Behnke, Stefanie" sort="Behnke, Stefanie" uniqKey="Behnke S" first="Stefanie" last="Behnke">Stefanie Behnke</name><name sortKey="Dillmann, Ulrich" sort="Dillmann, Ulrich" uniqKey="Dillmann U" first="Ulrich" last="Dillmann">Ulrich Dillmann</name><name sortKey="Gaenslen, Alexandra" sort="Gaenslen, Alexandra" uniqKey="Gaenslen A" first="Alexandra" last="Gaenslen">Alexandra Gaenslen</name><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><name sortKey="Godau, Jana" sort="Godau, Jana" uniqKey="Godau J" first="Jana" last="Godau">Jana Godau</name><name sortKey="Liepelt, Inga" sort="Liepelt, Inga" uniqKey="Liepelt I" first="Inga" last="Liepelt">Inga Liepelt</name><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name><name sortKey="Santo, Adriana Di" sort="Santo, Adriana Di" uniqKey="Santo A" first="Adriana Di" last="Santo">Adriana Di Santo</name><name sortKey="Schweitzer, Katherine" sort="Schweitzer, Katherine" uniqKey="Schweitzer K" first="Katherine" last="Schweitzer">Katherine Schweitzer</name><name sortKey="Wolf, Bjorn" sort="Wolf, Bjorn" uniqKey="Wolf B" first="Björn" last="Wolf">Björn Wolf</name><name sortKey="Wollenweber, Frank" sort="Wollenweber, Frank" uniqKey="Wollenweber F" first="Frank" last="Wollenweber">Frank Wollenweber</name></country><country name="Autriche"><noRegion><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name></noRegion><name sortKey="Kiechl, Stefan" sort="Kiechl, Stefan" uniqKey="Kiechl S" first="Stefan" last="Kiechl">Stefan Kiechl</name><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><name sortKey="Stockner, Heike" sort="Stockner, Heike" uniqKey="Stockner H" first="Heike" last="Stockner">Heike Stockner</name><name sortKey="Willeit, Johann" sort="Willeit, Johann" uniqKey="Willeit J" first="Johann" last="Willeit">Johann Willeit</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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